SARS-CoV-2 Nsp5 Protein Causes Acute Lung Inflammation, A Dynamical Mathematical Model

In the present work we propose a dynamical mathematical model of lung cells inflammation process in response to SARS-CoV-2 infection. this scenario main protease Nsp5 enhances inflammatory process, increasing levels NF kB, IL-6, Cox2, and PGE2 with respect reference state without virus. presence virus translation rates kB IkB arise high constant value, when rate IL-6 also increases above threshold value 7 pg mL −1 s predicts persistent over stimulated immune cytokine IL-6. Our shows how such becomes autonomous signals from other as macrophages lymphocytes, does not shut down by itself. We show that context presented here, Dexamethasone or Nimesulide have little effect on infected cell, only form suppress it is inhibition activity viral protein Nsp5. To end, our suggest drugs like Saquinavir may be useful. form, suggests effectively central node underlying severe acute during The production can one causes storm observed critical patients COVID19. seems switch start inflammation, consequent overproduction ACE2 receptor, an important cause most cases